TRIM13 antibody (Middle Region)

Catalog No. ABIN1109332

Product Details anti-TRIM13 Antibody

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequence: DTLETSKRKS LQLLTKDSDK VKEFFEKLQH TLDQKKNEIL SDFETMKLAV

Cross-Reactivity (Details): Species reactivity (expected):Rat, Mouse, BovineSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-TRIIM13 antibody: synthetic peptide directed towards the middle region of human TRIM13

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for TRIM13

Target: TRIM13 (Tripartite Motif Containing 13 (TRIM13))

Alternative Name: TRIM13 / RNF77 (TRIM13 Products)

Synonyms: TRIM13 antibody, RFP2 antibody, CAR antibody, DLEU5 antibody, LEU5 antibody, RNF77 antibody, 3110001L12Rik antibody, Rfp2 antibody, tripartite motif containing 13 antibody, ret finger protein 2 antibody, tripartite motif-containing 13 antibody, TRIM13 antibody, LOC100338599 antibody, Trim13 antibody

Background: TRIM13 is an E3 ubiquitin ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. TRIM13 enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation, regulates ER stress-induced autophagy, and may act as a tumor suppressor.Synonyms: B-cell chronic lymphocytic leukemia tumor suppressor Leu5, LEU5, Leukemia-associated protein 5, Putative tumor suppressor RFP2, RFP2, RING finger protein 77, Tripartite motif-containing protein 13

Gene ID: 10206

NCBI Accession: NP_005789