TSHZ3 antibody (Middle Region)

Catalog No. ABIN1109362

This Rabbit Polyclonal antibody specifically detects TSHZ3 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TSHZ3 antibody (Middle Region) (ABIN1109362)

Target: TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSHZ3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TSHZ3 Antibody

Binding Specificity: Middle Region

Sequence: LNVEVKKEVD KEKAVTDEKP KQKDKPGEEE EKCDISSKYH YLTENDLEES

Cross-Reactivity (Details): Species reactivity (expected):Mouse, RatSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogen: The immunogen for anti-ZNF537 antibody: synthetic peptide directed towards the middle region of human ZNF537.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Target Details for TSHZ3

Target: TSHZ3 (Teashirt Zinc Finger Homeobox 3 (TSHZ3))

Alternative Name: TSHZ3 / ZNF537

Background: TSHZ3 is a transcriptional regulator involved in developmental processes. It function in association with APBB1, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. TSHZ3-mediated transcription repression involves the recruitment of histone deacetylases HDAC1 and HDAC2. TSHZ3 associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) and regulates the development of neurons involved in both respiratory rhythm and airflow control. It promotes maintenance of nucleus ambiguus (nA) motoneurons, which govern upper airway function, and establishes a respiratory rhythm generator (RRG) activity compatible with survival at birth. TSHZ3 ot ZNF537 is involved in the differentiation of the proximal uretic smooth muscle cells during developmental processes and in the up-regulation of myocardin, that directs the expression of smooth muscle cells in the proximal ureter.Synonyms: KIAA1474, TSH3, Teashirt homolog 3, Zinc finger protein 537

Gene ID: 57616

NCBI Accession: NP_065907

Pathways: Regulation of Muscle Cell Differentiation