Tumor Protein p73 antibody (C-Term)

Catalog No. ABIN1109413

This Rabbit Polyclonal antibody specifically detects Tumor Protein p73 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Tumor Protein p73 antibody (C-Term) (ABIN1109413)

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tumor Protein p73 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Tumor Protein p73 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects Tumor protein p73 (alpha) at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, mouse, rat

Purification: Immunogen affinity purified

Immunogen: A peptide mapping at the C-terminal end of human P73a .Remarks: Sequence differs from the related rat sequence by single amino acid.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 50 % glycerol, 0.9 mg NaCl, 0.2 mg Na2HPO4

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Target Details for Tumor Protein p73

Target: Tumor Protein p73 (TP73) (Tumor Protein P73 (TP73))

Background: P73 is a substrate of the c-Abl kinase and that the ability of c-Abl to phosphorylate p73 is markedly increased by gamma-irradiation. Moreover, p73 was phosphorylated in vivo in response to ionizing radiation. p73, a member of the p53 family of tumour-suppressor proteins, can also induce apoptosis.p73 gene is mapped to chromosome 1p36. p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage.Synonyms: p53-like transcription factor, p53-related protein

Gene ID: 7161

NCBI Accession: NP_001119712

UniProt: O15350

Pathways: Regulation of Cell Size, Positive Regulation of Response to DNA Damage Stimulus