PRSS1 antibody

Catalog No. ABIN7101954

Product Details anti-PRSS1 Antibody

Target: PRSS1 (Protease, serine, 1 (Trypsin 1) (PRSS1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRSS1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Specificity: Human pancreatic trypsin. Recognizes specifically pancreatic trypsin. Does not cross react with Pancreatic Chymotrypsin.

Purification: Protein G affinity chromatography.

Immunogen: Purified human pancreatic trypsin

Clone: 401

Isotype: IgG2b

Application Details

Application Notes: ELISA: May be used in immunoassays to detect and quantitate Pancreatic Trypsin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL (OD 280 nm)

Buffer: PBS, pH 7.4 without preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.

Target Details for PRSS1

Target: PRSS1 (Protease, serine, 1 (Trypsin 1) (PRSS1))

Alternative Name: Trypsin-1 / PRSS1 (PRSS1 Products)

Synonyms: TRP1 antibody, TRY1 antibody, TRY4 antibody, TRYP1 antibody, LOC397853 antibody, Trypsin antibody, wu:fb57g08 antibody, zgc:109701 antibody, Dvtry-1 antibody, dvir_GLEANR_6853 antibody, DvirGJ21500 antibody, GJ21500 antibody, Try1 antibody, PTRYI antibody, RATPTRYI antibody, Try-1 antibody, Trygn16 antibody, protease, serine 1 antibody, protease, serine 1 L homeolog antibody, trypsin-1 antibody, Trypsin-1 antibody, trypsin I antibody, protease, serine 1 (trypsin 1) antibody, protease, serine, 1 (trypsin 1) antibody, PRSS1 antibody, prss1.L antibody, prss1 antibody, CpipJ_CPIJ000708 antibody, CpipJ_CPIJ007079 antibody, CpipJ_CPIJ007080 antibody, CpipJ_CPIJ012156 antibody, CpipJ_CPIJ016225 antibody, CpipJ_CPIJ016619 antibody, CpipJ_CPIJ018339 antibody, Dvir\Try1 antibody, trp-i antibody, Prss1 antibody

Background: The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3, also known as Trypsin-4, is expressed in the brain in addition to the pancreas.Synonyms: Beta-trypsin, Cationic trypsinogen, Serine protease 1, TRP1, TRY1, TRYP1, Trypsin I

Gene ID: 5644

NCBI Accession: NP_002760

UniProt: P07477