PRSS1 antibody

Catalog No. ABIN111104

The Mouse Monoclonal anti-PRSS1 antibody is suitable to detect PRSS1 in samples from Human. It has been validated for EIA.

Quick Overview for PRSS1 antibody (ABIN111104)

Target: PRSS1 (Protease, serine, 1 (Trypsin 1) (PRSS1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRSS1 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Clone: 401

Product Details anti-PRSS1 Antibody

Specificity: Human pancreatic trypsin. Recognizes specifically pancreatic trypsin. Does not cross react with Pancreatic Chymotrypsin.

Purification: Protein G affinity chromatography.

Immunogen: Purified human pancreatic trypsin

Isotype: IgG2b

Application Details

Application Notes: ELISA: May be used in immunoassays to detect and quantitate Pancreatic Trypsin.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL (OD 280 nm)

Buffer: PBS, pH 7.4 without preservatives.

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.

Target Details for PRSS1

Target: PRSS1 (Protease, serine, 1 (Trypsin 1) (PRSS1))

Alternative Name: Trypsin-1 / PRSS1

Background: The human pancreas secretes three different isoforms of the inactive trypsinogen into the small intestine, namely cationic trypsinogen, anionic trypsinogen (the two major isoforms) and mesotrypsinogen (a minor isoform). In the small intestine, each isoform is cleaved by Enterokinase into its active form, Trypsin-1, Trypsin-2 and Trypsin-3, respectively. All trypsins are members of the serine protease trypsin family. The activated trypsins go on to activate other protease zymogens and play a role in the autoactivation of trypsinogens. This suggests an important role for trypsins in digestion. Mutations in the gene encoding Trypsin-1 that stimulate its activity are associated with autosomal dominant hereditary pancreatitis (HCP), also known as chronic pancreatitis (CP), a disease characterized by persistent, severe abdominal pain due to calcifications of the parenchyma, pancreatic stones, cysts and pancreatic head enlargement. Trypsin-3, also known as Trypsin-4, is expressed in the brain in addition to the pancreas.Synonyms: Beta-trypsin, Cationic trypsinogen, Serine protease 1, TRP1, TRY1, TRYP1, Trypsin I

Gene ID: 5644

NCBI Accession: NP_002760

UniProt: P07477