Annexin a1 antibody (N-Term)

Catalog No. ABIN1112715

This anti-Annexin a1 antibody is a Rabbit Polyclonal antibody detecting Annexin a1 in WB. Suitable for Dog and Monkey.

Quick Overview for Annexin a1 antibody (N-Term) (ABIN1112715)

Target: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Reactivity: Dog, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Annexin a1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Annexin a1 Antibody

Binding Specificity: N-Term

Specificity: Detect endogenous level of total Annexin A1 protein.

Immunogen: A synthetic peptide (conjugated to KLH) corresponding to N-terminal residues of human Annexin A1.

Isotype: IgG

Application Details

Application Notes: Western Blot (1:1000) Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Preservative: Sodium azide, Thimerosal (Merthiolate)

Storage: -20 °C

Storage Comment: Store at -20 °C for 1 year. Avoid repeated freeze and thaw cycles.

Expiry Date: 12 months

Target Details for Annexin a1

Target: Annexin a1 (ANXA1) (Annexin A1 (ANXA1))

Alternative Name: Annexin A1

Background: Annexin A1 / Annexin I also known as lipocortin I is a protein that in humans is encoded by the ANXA1 gene. Annexin I belongs to the annexin family of Ca2+-dependent phospholipid-binding proteins that have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Annexin I has been of interest for use as a potential anticancer drug. It inhibits the NF- kappa B signal transduction pathway, which is exploited by cancerous cells to proliferate and avoid apoptosis. ANXA1 inhibits the activation of NF-kappaB by binding to the p65 subunit.

Pathways: Hormone Transport