Tyrosine Hydroxylase antibody

Catalog No. ABIN1112833

This Mouse Monoclonal antibody specifically detects Tyrosine Hydroxylase in WB, IHC, IHC (p) and IHC (fro). It exhibits reactivity toward Rat, Mouse and Rabbit.

Quick Overview for Tyrosine Hydroxylase antibody (ABIN1112833)

Target: Tyrosine Hydroxylase (TH)

Reactivity: Rat, Mouse, Rabbit

Host: Mouse

Clonality: Monoclonal

Conjugate: This Tyrosine Hydroxylase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: N37

Product Details anti-Tyrosine Hydroxylase Antibody

Immunogen: Purified rat TH.

Isotype: IgG1

Application Details

Application Notes: WB (1:100-400), IHC-P (1:50-200), IHC-Fr (1:100-500). Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: TBS (0.1M), 30% Glycerol and 0.01% Sodium Azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Expiry Date: 12 months

Target Details for Tyrosine Hydroxylase

Target: Tyrosine Hydroxylase (TH)

Alternative Name: Tyrosine Hydroxylase

Background: Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). In humans, tyrosine hydroxylase is encoded by the TH gene, and the enzyme is present in the central nervous system (CNS), peripheral symphatic neurons and the adrenal medulla. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons. It also can be inhibited by the drug alpha-methyl-para-tyrosine (metirosine). This drug is rarely used and can cause depression, but it is useful in treating pheochromocytoma and also resistant hypertension.

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour