8-OHDG antibody

Catalog No. ABIN111330

The Mouse Monoclonal anti-8-OHDG antibody (Clone 15A3) (ABIN111330) specifically detects 8-OHDG in EIA, IHC (fro) and IF.

Quick Overview for 8-OHDG antibody (ABIN111330)

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Host: Mouse

Clonality: Monoclonal

Conjugate: This 8-OHDG antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Clone: 15A3

Product Details anti-8-OHDG Antibody

Purification: Protein G Chromatography.

Immunogen: 8-Hydroxyguanosine (OH8G)-BSA and -casein conjugates.

Isotype: IgG2b

Application Details

Application Notes: Suitable for use in ELISA and Immunohistochemistry (PLP-fixed sections) to detect themarkers of oxidative damage to DNA and RNA. May also be used on Immunoaffinity columns to isolate oxidative DNA damage adductsfrom biological fluids.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL (OD 280 nm)

Buffer: TBS, pH 7.4 with 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Target Details for 8-OHDG

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Alternative Name: 8-Hydroxy-Guanosine / 8-OHG

Target Type: Chemical

Background: 8 Hydroxyguanosine (80G) is a modified base which occurs in DNA as a result of oxidative stress. 8 Hydroxy-2'deoxyguanosine (8OHdG) has become a sensitive marker of oxidative damage in cellular DNA and has been reported to be excreted in the urine. Levels of 8OHdG have been shown to increase on exposure to ionizing radiation and tobacco smoke.Synonyms: 8-Hydroxy-2'-deoxyguanosine, 8-Hydroxyguanine, 8-Hydroxyguanosine, 8-OFdG, 8-OHG, 8OG, 8OHG, 8OHdG