Lactoferrin antibody

Catalog No. ABIN113036

The Rabbit Polyclonal anti-Lactoferrin antibody is suitable to detect Lactoferrin in samples from Human. It has been validated for EIA and IEP.

Quick Overview for Lactoferrin antibody (ABIN113036)

Target: Lactoferrin (LTF) (Lactotransferrin (LTF))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lactoferrin antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Immunoelectrophoresis (IEP)

Product Details anti-Lactoferrin Antibody

Purification: Immunoaffinity Chromatography using antigens coupled to agarose beads

Immunogen: Lactoferrin purified from Human colostrum

Application Details

Application Notes: ELISA. IEP.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 2.2 mg/mL

Buffer: 0.01 M Sodium Phosphate, 0.21 M Sodium Chloridel, pH 7.6 with no preservatives

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Target Details for Lactoferrin

Target: Lactoferrin (LTF) (Lactotransferrin (LTF))

Alternative Name: Lactotransferrin

Background: Lactoferrin belongs to a family of iron-binding proteins that modulate iron metabolism, hemopoiesis, and immunologic reactions, together with transferrin and melanoma tumor antigen p97. They are evolutionary products of gene duplication and all 3 are encoded by genes on 3q. Lactoferrin is an iron binding glycoprotein with an approximate molecular weight of 80 kDa. The protein has two iron binding domains each housing one Fe3+ and the synergistic CO32- ion. The crystal structure form of human lactoferrin at 2.2A resolution exhibits 5330 protein atoms, 2Fe2+, 2CO32- and 98 carbohydrate atoms. Lactoferrin is absorbed from intestine by apical side of the membrane and localized to the nuclei. Intravenous infusion of lactoferrin is protective against lethal doses of E coli and induce bacterimia by a mechanism that downregulates neutrophil TNF alfa secretion. Recombinant human lactoferrin (rhLF), expressed and extracted from rice seed, is being evaluated for use as a dietary supplement to treat iron deficiency and/or iron deficiency induced anemia. Lactoferrin has been shown to have a role in the immune system and in early development of the embryo. A specific receptor for lactoferrin binding has been implicated in the human fetal intestine. Early embryonic localisation of lactoferrin by IHC has suggested its presence in various tissues including intestinal epitheliuem, kiney, and various regions of the brain.Synonyms: EC=3.4.21, LF, LTF, Lactoferrin, Talalactoferrin

Gene ID: 9606

UniProt: P02788

Pathways: Transition Metal Ion Homeostasis