ITM2B antibody

Catalog No. ABIN113338

This Chicken Polyclonal antibody specifically detects ITM2B in IHC (fro). It exhibits reactivity toward Human.

Quick Overview for ITM2B antibody (ABIN113338)

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Reactivity: Human

Host: Chicken

Clonality: Polyclonal

Conjugate: This ITM2B antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ITM2B Antibody

Sequence: CSRTVKKNII EEN

Specificity: The antibody recognizes the typical amyloid deposits in brains of patients suffering from the disease. This antibody has been developed against the carboxy terminal extracellular sequence of the mutated BRI protein.

Purification: Affinity chromatography.

Immunogen: Peptide coupled to carrier protein.

Application Details

Application Notes: Suitable for Immunohistochemistry on frozen sections. Suggested positive control: pathological brain sections. (Not recommended in Western blots).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg /ml

Buffer: PBS, pH 7.2, containing 0.09 % sodium azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody at 2-8 °C (Lyophilized) or reconstituted in small aliquots at -20 °C.

Target Details for ITM2B

Target: ITM2B (Integral Membrane Protein 2B (ITM2B))

Alternative Name: ITM2B

Background: The mutated BRI protein (ITM2B) was identified in patients with familial British dementia. The unusual 277 residue precursor protein releases a 34-residue amyloidogenic peptide by the action of the protease furin, leading to the deposition of a protein fragment that seems to be involved in the pathogenesis of familial British dementia.Synonyms: BRI, BRI2, ITM2B, Integral membrane protein 2B, Transmembrane protein BRI

Gene ID: 9445

NCBI Accession: NP_068839

UniProt: Q9Y287