CD8B antibody

Catalog No. ABIN114185

The Rat Monoclonal anti-CD8B antibody is suitable to detect CD8B in samples from Mouse. It has been validated for FACS.

Quick Overview for CD8B antibody (ABIN114185)

Target: CD8B (CD8b Molecule (CD8B))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD8B antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: CT-CD8b

Product Details anti-CD8B Antibody

Specificity: This anti-mouse CD8 b-Chain monoclonal antibody is specific for most thymocytes, cytotoxic/suppressor T-cells and their precursors. The CD8 b-Chain is also named Ly-3.

Purification: Purified

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry Analysis (see Protocols).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Protocol: FLOW CYTOMETRY ANALYSIS:

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: PBS and 0.1 % NaN3

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CD8B

Target: CD8B (CD8b Molecule (CD8B))

Alternative Name: CD8 beta

Background: The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell to cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains.Synonyms: CD8B, CD8B1, T-cell surface glycoprotein CD8 beta chain

Gene ID: 12526

NCBI Accession: NP_033988

UniProt: P10300

Pathways: TCR Signaling