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Ezrin antibody (AA 362-585)

Name: Ezrin antibody (AA 362-585)
SKU: ABIN115201
Price: 1244.4 USD
Availability: InStock

EZR Reactivity: Human, Mouse, Rat, Cow, Hamster, Kangaroo WB, IHC (p), IP Host: Mouse Monoclonal 3C12 unconjugated

Formalin fixed paraffin embedded human lung stained with Ezrin antibody.

IHC

1 image

(2 references)

Catalog No. ABIN115201

Datasheet as PDF

Target See all Ezrin (EZR) Antibodies

Ezrin (EZR)
Binding Specificity
29

16

12

11

9

9

9

8

5

5

4

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 362-585
Reactivity
153

81

74

8

7

7

5

4

3

3

3

1

1

1

1
Human, Mouse, Rat, Cow, Hamster, Kangaroo
Host
141

11

3

2
Mouse
Compatible Secondaries
Clonality
138

18
Monoclonal
Conjugate
89

8

7

7

7

7

7

7

4

3

2

2

2

2

2

1
This Ezrin antibody is un-conjugated
Application
117

54

25

17

16

13

13

13

10

9

3

2

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Specificity

This antibody reacts with a protein of 81 kDa.
Cellular Localization: Cell membrane

Purification

Purified

Immunogen

BALB/C mice were immunized with a recombinant fragment of human ezrin corresponding to amino acid 362-585.

Clone

3C12

Isotype

IgG1

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EZR Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

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anti-Ezrin (EZR) (AA 1-586) antibody
EZR Reactivity: Human WB, IP Host: Rabbit Polyclonal unconjugated

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EZR Reactivity: Human, Mouse, Rat WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated

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EZR Reactivity: Human WB, IHC, StM Host: Mouse Monoclonal CPTC-Ezrin-1 unconjugated

anti-Ezrin (EZR) (AA 1-586) antibody
EZR Reactivity: Human WB, ELISA, IHC (p), PLA Host: Mouse Monoclonal 1E11 unconjugated

anti-Ezrin (EZR) (AA 350-470) antibody
EZR Reactivity: Human WB, IP, IF Host: Rabbit Polyclonal unconjugated

anti-Ezrin (EZR) (AA 1-251) antibody
EZR Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Ezrin (EZR) (AA 455-586) antibody
EZR Reactivity: Human, Rat WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

Application Notes

Immunoprecipitation. Western blot: 1: 100-750. Immunohistochemistry on paraffin embedded sections: dilute 1: 50-1: 100 in an ABC method(30 minutes at room temperature). Recommended positive control: Lung.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions

For Research Use only
Format

Liquid

Handling Advice

Avoid repeated freezing and thawing.

Storage

4 °C/-20 °C

Storage Comment

Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Hatano, Akiyama, Tamura, Hosogi, Marunaka, Caplan, Ueno, Tsukita, Asano: "Knockdown of ezrin causes intrahepatic cholestasis by the dysregulation of bile fluidity in the bile duct epithelium in mice." in: Hepatology (Baltimore, Md.), Vol. 61, Issue 5, pp. 1660-71, (2015) (PubMed).

Fonseca, Freund, Bornhäuser, Corbeil: "Polarization and migration of hematopoietic stem and progenitor cells rely on the RhoA/ROCK I pathway and an active reorganization of the microtubule network." in: The Journal of biological chemistry, Vol. 285, Issue 41, pp. 31661-71, (2010) (PubMed).
Target

Ezrin (EZR)

Alternative Name

Ezrin (EZR Products)

Synonyms

CVIL antibody, CVL antibody, VIL2 antibody, ezr antibody, vil2 antibody, wu:fc05c03 antibody, wu:fj31d06 antibody, cvil antibody, cvl antibody, Vil2 antibody, AW146364 antibody, R75297 antibody, p81 antibody, ezr.S antibody, ezrin antibody, ezrin b antibody, ezrin L homeolog antibody, EZR antibody, ezrb antibody, ezr antibody, Ezr antibody, ezr.L antibody

Background

Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF-stimulated cells. Ezrin is a cytoplasmic protein enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas.Synonyms: Cytovillin, EZR, VIL2, Villin-2, p81

Gene ID

7430

NCBI Accession

NP_001104547

UniProt

P15311

Pathways

Maintenance of Protein Location