NAMPT antibody

Catalog No. ABIN1169025

Cited in 3+ publications. The Rabbit Polyclonal anti-NAMPT antibody (ABIN1169025) specifically detects NAMPT in WB, IHC and ELISA. The antibody is reactive with Human samples.

Quick Overview for NAMPT antibody (ABIN1169025)

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAMPT antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-NAMPT Antibody

Purpose: anti-Nampt (Visfatin/PBEF) (human), pAb

Specificity: Recognizes human Nampt. Weakly cross-reacts with mouse Nampt. Detects a band of ~54 kDa by Western blot.

Cross-Reactivity (Details): Weakly cross-reacts with mouse Nampt.

Characteristics: Polyclonal Antibody. Recognizes human Nampt. Weakly cross-reacts with mouse Nampt. Detects a band of ~54 kDa by Western blot. Source: Rabbit. Applications: ELISA, IHC, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Nampt also known as pre-B cell colony-enhancing factor 1 (PBEF1) or visfatin is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human Nampt (visfatin/PBEF).

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

References for anti-NAMPT antibody (ABIN1169025)

Moschen, Kaser, Enrich, Mosheimer, Theurl, Niederegger, Tilg: "Visfatin, an adipocytokine with proinflammatory and immunomodulating properties." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 3, pp. 1748-58, (2007) (PubMed).

Nowell, Richards, Fielding, Ognjanovic, Topley, Williams, Bryant-Greenwood, Jones: "Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis." in: Arthritis and rheumatism, Vol. 54, Issue 7, pp. 2084-95, (2006) (PubMed).

Bae, Kim, Kim, Kim, Koo, Jang, Yun, Yoo, Bae: "Hypoxic induction of human visfatin gene is directly mediated by hypoxia-inducible factor-1." in: FEBS letters, Vol. 580, Issue 17, pp. 4105-13, (2006) (PubMed).

Target Details for NAMPT

Target: NAMPT (Nicotinamide phosphoribosyltransferase (NAMPT))

Alternative Name: Nampt (Visfatin/PBEF)

Background:

Alternate Names/Synonyms: Pre-B Cell Colony Enhancing Factor 1, PBEF1, Nicotinamide Phosphoribosyltransferase

Product Description: Nampt also known as pre-B cell colony-enhancing factor 1 (PBEF1) or visfatin is an adipokine that is localized to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.

UniProt: P43490