Clusterin antibody (Nuclear) (Biotin)

Catalog No. ABIN1169058

The Biotin-conjugated Rabbit Polyclonal anti-Clusterin antibody (ABIN1169058) specifically detects Clusterin in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for Clusterin antibody (Nuclear) (Biotin) (ABIN1169058)

Target: Clusterin (CLU)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Clusterin antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA

Product Details anti-Clusterin Antibody (Biotin)

Binding Specificity: Nuclear

Purpose: anti-Clusterin (human), pAb (Biotin)

Specificity: Recognizes human clusterin. Detects a band of ~49 kDa by Western blot.

Characteristics: Polyclonal Antibody. Recognizes human clusterin. Detects a band of ~49 kDa by Western blot. Source: Rabbit. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human clusterin (nuclear form).

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: Clusterin

Background:

Alternate Names/Synonyms: TRPM-2, Apolipoprotein J, APO-J, CLI, CLU, SGP-2

Product Description: Clusterin shares homology with the small heat shock protein family of molecular chaperones. The mature secreted form of the protein is a glycosylated, 80- kDa disulfide-linked heterodimer of alpha and beta subunits (produced by internal cleavage). Clusterin is expressed in virtually all tissues and found in all human fluids. It is involved in numerous physiological processes important for carcinogenesis and tumor growth, including apoptotic cell death, cell cycle regulation, DNA repair, cell adhesion, tissue remodeling, lipid transportation, membrane recycling, and immune system regulation. Clusterin also exists as a nuclear protein. The secreted form of Clusterin has extracellular chaperone and anti-apoptotic activities while the nuclear form acts as a proapoptotic factor.

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling