SIRT6 antibody
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- Target See all SIRT6 Antibodies
- SIRT6 (Sirtuin 6 (SIRT6))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SIRT6 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Specificity
- Recognizes human sirtuin 6. Detects a band of ~42 kDa by Western blot.
- Cross-Reactivity
- Human
- Sterility
- 0.2 μm filtered
- Immunogen
- Recombinant human sirtuin 6.
- Top Product
- Discover our top product SIRT6 Primary Antibody
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
- Preservative
- Without preservative
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- SIRT6 (Sirtuin 6 (SIRT6))
- Alternative Name
- Sirtuin 6 (SIRT6 Products)
- Synonyms
- 2810449N18Rik antibody, AI043036 antibody, Sir2l6 antibody, SIR2L6 antibody, zgc:86729 antibody, sirtuin 6 antibody, sirtuin 6 S homeolog antibody, Sirt6 antibody, SIRT6 antibody, sirt6.S antibody, sirt6 antibody
- Background
- Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.
- UniProt
- Q8N6T7
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