SIRT6 antibody

Catalog No. ABIN1169069

The Mouse Monoclonal anti-SIRT6 antibody is suitable to detect SIRT6 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for SIRT6 antibody (ABIN1169069)

Target: SIRT6 (Sirtuin 6 (SIRT6))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIRT6 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: S6R82-2

Product Details anti-SIRT6 Antibody

Purpose: anti-Sirtuin 6 (human), mAb (S6R82-2)

Specificity: Recognizes human sirtuin 6. Detects a band of ~47 kDa by Western blot.

Characteristics: Monoclonal Antibody. Recognizes human sirtuin 6. Detects a band of ~47 kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S6R82-2. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human sirtuin 6.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for SIRT6

Target: SIRT6 (Sirtuin 6 (SIRT6))

Alternative Name: Sirtuin 6

Background:

Alternate Names/Synonyms: SIRT6, NAD-dependent Deacetylase Sirtuin-6, Mono-ADP-ribosyltransferase Sirtuin 6, SIR2-like Protein 6, SIR2L6

Product Description: Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.

UniProt: Q8N6T7