Stearoyl-Coenzyme A Desaturase 1 (SCD1) (AA 21-33) antibody

Catalog No. ABIN1169094

The Rabbit Polyclonal anti-Stearoyl-Coenzyme A Desaturase 1 antibody (ABIN1169094) specifically detects Stearoyl-Coenzyme A Desaturase 1 in WB and ELISA. The antibody is reactive with Mouse samples.

Quick Overview for Stearoyl-Coenzyme A Desaturase 1 (SCD1) (AA 21-33) antibody (ABIN1169094)

Target: Stearoyl-Coenzyme A Desaturase 1 (SCD1)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Product Details

Binding Specificity: AA 21-33

Purpose: anti-Stearoyl-CoA Desaturase-1 (mouse), pAb

Specificity: Recognizes mouse SCD1. Detects a band of ~41 kDa by Western Blot.

Characteristics: Polyclonal Antibody. Recognizes mouse SCD1. Detects a band of ~41 kDa by Western Blot. Source: Rabbit. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The enzyme is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. Several SCD isoforms (SCD1, -2, and -3) exist in the mouse. Mice with a targeted disruption of the SCD1 isoform had reduced body adiposity, increased insulin sensitivity, and resistance to diet-induced weight gain. The protection from obesity involved increased energy expenditure and increased oxygen consumption. SCD1 deficiency shows activation of lipid oxidation in addition to reduced triglyceride synthesis and storage.

Sterility: 0.2 μm filtered

Immunogen: Synthetic peptide corresponding to aa 21-33 (A21PPSGNEREKVKT33) of mouse SCD1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details

Target: Stearoyl-Coenzyme A Desaturase 1 (SCD1)

Alternative Name: Stearoyl-CoA Desaturase-1

Background:

Alternate Names/Synonyms: SCD1, Acyl-CoA Desaturase 1, Fatty Acid Desaturase 1

Product Description: Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The enzyme is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. Several SCD isoforms (SCD1, -2, and -3) exist in the mouse. Mice with a targeted disruption of the SCD1 isoform had reduced body adiposity, increased insulin sensitivity, and resistance to diet-induced weight gain. The protection from obesity involved increased energy expenditure and increased oxygen consumption. SCD1 deficiency shows activation of lipid oxidation in addition to reduced triglyceride synthesis and storage.

UniProt: P13516

Pathways: Brown Fat Cell Differentiation