LAG3 antibody (N-Term) (Biotin)

Catalog No. ABIN1169110

This Mouse Monoclonal antibody specifically detects LAG3 in ELISA. It exhibits reactivity toward Human.

Quick Overview for LAG3 antibody (N-Term) (Biotin) (ABIN1169110)

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LAG3 antibody is conjugated to Biotin

Application: ELISA

Clone: 17B4

Product Details anti-LAG3 Antibody (Biotin)

Binding Specificity: N-Term

Specificity: Recognizes human LAG-3.

Cross-Reactivity: Human

Endotoxin Level: <0.001EU/μg purified protein or <1EU /mg purified protein (LAL test, Lonza).

Immunogen: Synthetic peptide corresponding to 30 aa in the N-terminus of human LAG-3.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for LAG3

Target: LAG3 (Lymphocyte-Activation Gene 3 (LAG3))

Alternative Name: LAG-3

Background: Lymphocyte activation gene 3 (LAG-3, CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.

UniProt: P18627

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints