NMNAT2 antibody

Catalog No. ABIN1169223

The Guinea Pig Polyclonal anti-NMNAT2 antibody (ABIN1169223) specifically detects NMNAT2 in ELISA, WB and IHC. The antibody is reactive with Human samples.

Quick Overview for NMNAT2 antibody (ABIN1169223)

Target: NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))

Reactivity: Human

Host: Guinea Pig

Clonality: Polyclonal

Conjugate: This NMNAT2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NMNAT2 Antibody

Purpose: anti-NMNAT2 (human), pAb

Specificity: Recognizes human NMNAT2. Detects a band of ~35 kDa by Western blot. Not tested in other species.

Cross-Reactivity (Details): Not tested in other species.

Characteristics: Polyclonal Antibody. Recognizes human NMNAT2. Detects a band of ~35 kDa by Western blot. Not tested in other species. Source: Guinea pig. Applications: ELISA, IHC, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. NMNAT2 catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. Has been shown to correlate with Alzheimer's disease in APPswe/PS1dE9 transgenic mice and delayed wallerian degeneration in cultured superior cervical ganglia (SCGs) from morphological changes, microtubule destruction and neurofilament degradation.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human NMNAT2.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for NMNAT2

Target: NMNAT2 (Nicotinamide Nucleotide Adenylyltransferase 2 (NMNAT2))

Alternative Name: NMNAT2

Background:

Alternate Names/Synonyms: Nicotinamide Mononucleotide Adenylyltransferase 2, NMN Adenylyltransferase 2, NaMN Adenylyltransferase 2

Product Description: NMNAT2 catalyzes the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form nicotinic acid mononucleotide (NaMN) as a substrate but with lower efficiency. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD+. Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans. Has been shown to correlate with Alzheimer's disease in APPswe/PS1dE9 transgenic mice and delayed wallerian degeneration in cultured superior cervical ganglia (SCGs) from morphological changes, microtubule destruction and neurofilament degradation.

UniProt: Q9BZQ4