TNFRSF10A antibody

Catalog No. ABIN1169238

The Mouse Monoclonal anti-TNFRSF10A antibody (Clone TR1-02) (ABIN1169238) specifically detects TNFRSF10A in FACS and IHC. The antibody is reactive with Human samples.

Quick Overview for TNFRSF10A antibody (ABIN1169238)

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNFRSF10A antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC)

Clone: TR1-02

Product Details anti-TNFRSF10A Antibody

Purpose: anti-TRAIL-R1 (human), mAb (TR1.02)

Specificity: Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4.

Cross-Reactivity (Details): Does not cross-react with human TRAIL-R2, -R3 or -R4.

Characteristics: Monoclonal Antibody. Recognizes human TRAIL-R1. Does not cross-react with human TRAIL-R2, -R3 or -R4. Isotype: Mouse IgG2b. Clone: TR1.02. Applications: FACS, IHC. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

Purification: Purified from concentrated hybridoma tissue culture supernatant.

Purity: >95 % (SDS-PAGE)

Immunogen: Recombinant human TRAIL-R1 (DR4).

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Specially developed for the immunohistochemical detection of TRAIL-R1 in paraffin embedded tissue. Has been shown to detect TRAIL-R1 expressed at endogenous levels in paraffin-embedded tissue in different mammary carcinoma tissues.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for TNFRSF10A

Target: TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))

Alternative Name: TRAIL-R1

Background:

Alternate Names/Synonyms: TRAIL Receptor 1, DR4, APO2, TNFRSF10A, CD261

Product Description: TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

UniProt: O00220

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity