FOXP3 antibody

Catalog No. ABIN1169338

This Rabbit Polyclonal antibody specifically detects FOXP3 in WB and ELISA. It exhibits reactivity toward Mouse.

Quick Overview for FOXP3 antibody (ABIN1169338)

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXP3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-FOXP3 Antibody

Purpose: anti-FOXP3 (mouse), pAb

Specificity: Recognizes mouse FOXP3. Detects a band of ~46-48 kDa by Western blot.

Characteristics: Polyclonal Antibody. Recognizes mouse FOXP3. Detects a band of ~46-48 kDa by Western blot. Source: Rabbit. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.

Sterility: 0.2 μm filtered

Immunogen: Recombinant mouse FOXP3.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Alternative Name: FOXP3

Background:

Alternate Names/Synonyms: Forkhead Box Protein P3, Scurfin

Product Description: FOXP3 is involved in immune system responses. It functions as the master regulator in the development and function of regulatory T cells. FOX proteins belong to the forkhead/winged-helix family of transcriptional regulators and are presumed to exert control via similar DNA binding interactions during transcription. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema.

UniProt: Q99JB6

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation