NLRP1 antibody (N-Term)

Catalog No. ABIN1169419

This Rabbit Polyclonal antibody specifically detects NLRP1 in WB. It exhibits reactivity toward Human.

Quick Overview for NLRP1 antibody (N-Term) (ABIN1169419)

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NLRP1 Antibody

Binding Specificity: AA 2-25, N-Term

Specificity: Recognizes human NLRP1/NALP1.

Cross-Reactivity: Human

No Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): Does not cross-react with mouse NLRP1/NALP1.

Immunogen: Synthetic peptide corresponding to aa 2-25 (A2GGAWGRLACYLEFLKKEELKEFQ25) at the N-terminus of human NLRP1/NALP1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for NLRP1

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Alternative Name: NLRP1/NALP1

Background: NALP1/NLRP1 is able to form cytoplasmic structures termed death effector filaments. It enhances and stimulates apoptosis through activation of different caspase cascades. It is involved in the activation of caspase-1 and caspase-5 as part of the NALP1 inflammasome complex which leads to processing and release of IL1B and IL18. Genetic variations in the NLRP1/NALP1 gene are associated with susceptibility to vitiligo-associated multiple autoimmune disease type 1, an autoimmune disorder characterized by the association of vitiligo with several autoimmune and autoinflammatory diseases including autoimmune thyroid disease, rheumatoid arthritis and systemic lupus erythematosus.

UniProt: Q9C000

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome