PVRL2 antibody

Catalog No. ABIN119489

The Mouse Monoclonal anti-PVRL2 antibody has been validated for FACS, IP and IHC (fro). It is suitable to detect PVRL2 in samples from Human.

Quick Overview for PVRL2 antibody (ABIN119489)

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PVRL2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: R2-525

Product Details anti-PVRL2 Antibody

Specificity: This antibody recognises CD112 Poliovirus Receptor Related 2 (PRR2), a new surface molecule.

Purification: Affinity chromatography on Protein G

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: 1/50 - 1/100, Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Immunoprecipitation. Immunohistochemistry on frozen sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PVRL2

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Alternative Name: CD112 / Nectin 2

Background: CD112 has been reported to be homologous to the poliovirus receptor (CD155). Studies demonstrate that PRR2 expression is restricted to the myelo-monocytic and megakaryocytic lineages. PRR2 expression has also been detected on haematopoeitic progenitors expressing CD34.Synonyms: HVEB, Herpes virus entry mediator B, Nectin-2, PRR2, PVRL2, Poliovirus receptor-related protein 2

Gene ID: 5819

NCBI Accession: NP_001036189

UniProt: Q92692

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization