Human Adenovirus type 3 (HAdV-3) antibody

Catalog No. ABIN119927

Product Details

Target: Human Adenovirus type 3 (HAdV-3)

Reactivity: Adenovirus

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Affinity Chromatography on Protein A

Immunogen: Adenovirus type 3 (ATCC strain VR847) Remarks: Spleen cells from immunised BALB/c mice were fused with cells of the JK.Ag8.653 mouse myeloma cell line

Clone: B025 (AD51)

Isotype: IgG2a

Application Details

Application Notes: Immunohistochemistry on frozen and paraffin sections (requires protein digestion pre- treatment of paraffin sections, e.g. trypsin or pronase, prior to staining). ELISA
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details

Target: Human Adenovirus type 3 (HAdV-3)

Alternative Name: Adenovirus Type 3

Target Type: Virus

Background: Adenoviruses are DNA viruses generally widespread in nature that are frequently the cause of acute upper respiratory tract infections (i.e. common colds). Forty-seven known serotypes have been isolated since they were first discovered in 1953 with 3 types known to cause gastroenteritis. Several types have oncogenic potential though most cause self-limiting febrile illnesses characterised by inflammation of conjunctivae and the respiratory tract. The virus can be isolated from the majority of tonsils/adenoids surgically removed, indicating latent infections. It is not known how long the virus can persist in the body, or whether it is capable of reactivation after long periods. In patients experiencing immunosuppression (e.g. AIDS) it can be reactivated causing disease. Hexon protein is a major coat protein of adenoviruses. Adenoviruses capsids have three principal protein components: the hexon, the penton, and the fiber. Hexon consists of three subunits together forming two major components of different morphological symmetry. A triangular top with three towers of density is superimposed on a more bulky pseudo hexagonal base. The symmetry of the top is in accord with the trimeric nature of hexon, but that of the base derives from the molecular function, which is to provide a densely packed impenetrable protective outer layer for the virion.