MHC Class I RT1.Aa alpha-Chain (RT1.AA) antibody

Catalog No. ABIN120718

This Mouse Monoclonal antibody specifically detects in FACS, IHC (fro) and IP. It exhibits reactivity toward Rat.

Quick Overview for MHC Class I RT1.Aa alpha-Chain (RT1.AA) antibody (ABIN120718)

Target: MHC Class I RT1.Aa alpha-Chain (RT1.AA)

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)

Clone: OX-18

Product Details

Purification: Protein G Chromotraphy

Immunogen: Rat spleen membrane glycoproteins depleted of Ia-A antigens. Donor: BALB/c spleen. Fusion Partner: X63 Ag8.653

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS

Preservative: Azide free

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Handle under aseptic conditions.
Shelf Life: one year from despatch.

Expiry Date: 12 months

Target Details

Target: MHC Class I RT1.Aa alpha-Chain (RT1.AA)

Alternative Name: MHC Class I (RT1Aa)

Background: MHC Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. MHC class I antigens are heterodimers consisting of one alpha chain (44 kDa) with beta 2 microglobulin (11.5 kDa). The antigen is expressed by all somatic cells at varying levels. MHC Class I molecules are expressed on most nucleated cells where they present endogenously synthesized antigenic peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. Fibroblasts or neurons however only show a low level of antigen.Synonyms: RT1 class I histocompatibility antigen AA alpha chain