CRYAA
Reactivity: Human
WB, ELISA, IF, ICC
Host: Mouse
Monoclonal
1H3-B8
PE
Application Notes
ELISA. Western blot (1:500 - 1:2,000), recommended starting dilution 1:1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. Shelf Life: one year from despatch.
Crystallins alpha are composed of two gene products, alpha A and alpha B, for acidic and basic, respectively. crystallins alpha can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20). They act as molecular chaperones and hold them in large soluble aggregates. These heterogeneous aggregates consist of 30-40 subunits, the alpha A and alpha B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The expression of alpha-A is preferentially restricted to the lens cell.Synonyms: CRYA1, CRYAA, HSPB4, Heat shock protein beta-4