HTRA2 antibody (AA 134-458)

Catalog No. ABIN121159

Product Details anti-HTRA2 Antibody

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Binding Specificity: AA 134-458

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This HTRA2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human HtrA2/Omi (134-458 aa) purified from E. coli

Clone: 1B3

Isotype: IgG1

Application Details

Application Notes: ELISA. Western blot (1:500 - 1:2,000).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Expiry Date: 12 months

Target Details for HTRA2

Target: HTRA2 (HtrA Serine Peptidase 2 (HTRA2))

Alternative Name: HTRA2 / PRSS25 (HTRA2 Products)

Synonyms: CG8464 antibody, DmHtrA2 antibody, Dmel\\CG8464 antibody, HtrA2/Omi antibody, Omi antibody, dOmi antibody, domi antibody, htrA2 antibody, omi antibody, HTRA2 antibody, PRSS25 antibody, OMI antibody, PARK13 antibody, AI481710 antibody, Prss25 antibody, mnd2 antibody, HTRA2-related serine protease antibody, HtrA serine peptidase 2 antibody, HtrA2 antibody, HTRA2 antibody, htra2 antibody, Htra2 antibody

Background: HtrA2/Omi is a mammalian serine protease at high temperatures and a chaperone at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Recently, HtrA2 has been known to contribute both to caspase-dependent and caspase-independent cell death.Synonyms: High temperature requirement protein A2, OMI, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI, mitochondrial Serine protease HTRA2

UniProt: O43464

Pathways: Positive Regulation of Endopeptidase Activity