GPR3 antibody

Catalog No. ABIN122137

Product Details anti-GPR3 Antibody

Target: GPR3 (G Protein-Coupled Receptor 3 (GPR3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GPR3 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Reacts with G Protein-Coupled Receptor GPR3 (family: GPCR, subfamily: Lysophospholipid/Lysosphingolipid)

Purification: Peptide immunogen affinity column

Immunogen: Synthetic peptide - KLH conjugated

Application Details

Application Notes: Immunohistochemistry with formalin fixed paraffin embedded tissues: 6 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.7, containing 0.01 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-80 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for GPR3

Target: GPR3 (G Protein-Coupled Receptor 3 (GPR3))

Alternative Name: GPR3 / ACCA (GPR3 Products)

Synonyms: GPR3 antibody, ACCA antibody, Gpcr3 antibody, Gpcr20 antibody, Gpcr21 antibody, G protein-coupled receptor 3 antibody, G-protein coupled receptor 3 antibody, GPR3 antibody, Gpr3 antibody

Background: GPR3 has been identified as a constitutively active lysophospholipid/lysosphingolipid receptor. GPR3 receptor is a link in communication between the somatic cells and oocyte of the ovarian follicle where GPR3 maintains meiotic arrest in mouse oocytes. Oocytes from Gpr3 knockout mice resume meiosis within antral follicles, independently of an increase in luteinizing hormone, and this phenotype Mice deficient in GPR3 exhibit premature ovarian failure due to early oocyte aging. GPR3 has been reported at low abundance predominantly in the central nervous system and in the lung and kidney. ESTs have been isolated from brain and colon libraries.Synonyms: ACCA orphan receptor, G-protein coupled receptor 3

Gene ID: 2827

UniProt: P46089

Pathways: cAMP Metabolic Process