MAPK14 antibody (N-Term)

Catalog No. ABIN127010

The Rabbit Polyclonal anti-MAPK14 antibody is suitable to detect MAPK14 in samples from Human, Mouse and Rat. It has been validated for WB, IP and IHC (p).

Quick Overview for MAPK14 antibody (N-Term) (ABIN127010)

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK14 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-MAPK14 Antibody

Binding Specificity: N-Term

Specificity: The antibody detects p38 MAP kinase. It does not cross-react with either JNK/SAPK or p44/42 MAP kinase.

Purification: Affinity Purified

Immunogen: Synthetic peptide mapping to the N-terminus of human p38 MAP kinase

Application Details

Application Notes: Western blotting (0.5-4.0 μg/mL). Immunoprecipitation (10-20 μg/mL). Immunohistochemistry (10-20 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS containing 30 % glycerol, 0.5 % BSA, and 0.01 % thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store undiluted (in aliquots) at -20 °C to -70 °C.

Target Details for MAPK14

Target: MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))

Alternative Name: MAP Kinase p38 alpha / MAPK14

Background: P38 MAP kinase is the mammalian homologue of the yeast HOG kinase and participates in a cascade controlling cell cellular responses to cytokines and stress. Like the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including inflammatory cytokines, UV light and growth factors, etc. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase-2 and to phosphorylate the transcription factors ATF-2 and Max.Synonyms: CSBP, CSBP1, CSBP2, CSPB1, Cytokine suppressive anti-inflammatory drug-binding protein, MAX-interacting protein 2, MXI2, Mitogen-activated protein kinase 14, SAPK2A, p38 alpha

Gene ID: 1432

NCBI Accession: NP_001306

UniProt: Q16539

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagy, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteins