Caspase 6 antibody (C-Term)

Catalog No. ABIN127060

This Rabbit Polyclonal antibody specifically detects Caspase 6 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Caspase 6 antibody (C-Term) (ABIN127060)

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Caspase 6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Caspase 6 Antibody

Binding Specificity: C-Term

Specificity: The antibody detects a full length (35 kDa) and the cleaved fragment (18 kDa) of Caspase-6.

Purification: Affinity Purified

Immunogen: Synthetic peptide mapping to the C-terminus of Rat Caspase-6 large fragment.

Application Details

Application Notes: Western Blot: 0.5-4 μg/mL. Jurkat cell lysate, mouse intestine, and rat kidney tissue lysate can be used as a positivecontrols.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: PBS, pH 7.2 containing 30 % Glycero, 0.01 Thimerosal, 0.5 % BSA

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Target Details for Caspase 6

Target: Caspase 6 (CASP6) (Caspase 6, Apoptosis-Related Cysteine Peptidase (CASP6))

Alternative Name: Caspase-6

Background: Caspase family of cysteine proteases has been shown to play a key role in apoptosis. Caspase-6 is one of the major executioner caspases functioning in cellular apoptotic processes. Similar as other caspases, caspase-6 is also synthesized as an inactive pro-enzyme that is processed in cells undergoing apoptosis. Together with caspase-3, caspase-6 is one of the major caspases in apoptotic cells, and functions downstream of apoptosis inhibitors Bcl-2 and Bcl-xL. Caspase-6 has also been shown involving in the proteolysis of poly (ADP-ribose) polymerase (PARP) and nuclear lamin A.Synonyms: Apoptotic protease Mch-2, CASP-6, CASP6, MCH-2, MCH2

Gene ID: 839

NCBI Accession: NP_001217

UniProt: P55212

Pathways: Apoptosis, Caspase Cascade in Apoptosis