CAMP antibody

Catalog No. ABIN127195

Product Details anti-CAMP Antibody

Target: CAMP (cAMP) (Cyclic Adenosine Monophosphate (cAMP))

Reactivity: Please inquire

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMP antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Purification: Immunoaffinity purified

Immunogen: 2'-O-succinyl cAMP conjugated to BSA

Application Details

Application Notes: 1: 50 dilutions for nonradioactive EIA assays (10 μL/assay in an 70 μL assay reaction). Thematerial is sufficient for performing 500 nonradioactive EIA assays or 6,000 radioactiveassays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.02 % Sodium Azide, 50 % Glycerol, 1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Target Details for CAMP

Target: CAMP (cAMP) (Cyclic Adenosine Monophosphate (cAMP))

Alternative Name: cAMP / Cyclic AMP (cAMP Products)

Synonyms: CRAMP antibody, CAP-18 antibody, CAP18 antibody, FALL-39 antibody, FALL39 antibody, LL37 antibody, CAP11 antibody, Cnlp antibody, Cramp antibody, MCLP antibody, CATHL7 antibody, cathelicidin antimicrobial peptide antibody, Camp antibody, CAMP antibody

Target Type: Chemical

Background: Cyclic adenosine monophosphate (cAMP) plays a key role as an intracellular second messenger for transduction events that follow a number of extracellular signals. The G-Protein Coupled Receptors (GPCR) is the largest family of cell surface receptors. They can be activated by different ligands, such as neurotransmitters, hormones, ions, small molecules, peptides, and other physiological signaling molecules. Typically, the binding of the ligands to its receptor resulting in the activation of G-proteins, in return, activates the effector adenylyl cyclase evoking the production of cAMP. The activation of a protein kinase by cAMP results in the phosphorylation of substrate proteins. Currently successful drugs in marketing have been developed to target these receptors. Among the GPCRs, ~367 receptors are potential drug development targets, but only about 20 have been used to generate therapeutically and commercially successful drugs so far. Because the involvement of cAMP can amplify the response of the ligand binding, the second messenger cAMP has been largely employed to monitor the activation of the GPCR to facilitate the therapeutic drug discovery.

Pathways: Cellular Response to Molecule of Bacterial Origin