FKBP1A antibody

Catalog No. ABIN127265

The Rabbit Polyclonal anti-FKBP1A antibody is suitable to detect FKBP1A in samples from Human, Mouse, Rat, Cow and Rabbit. It has been validated for WB, IP and IHC (p).

Quick Overview for FKBP1A antibody (ABIN127265)

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Reactivity: Human, Mouse, Rat, Cow, Rabbit

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP1A antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-FKBP1A Antibody

Specificity: The antibody detects 12 kDa FKBP12 protein.

Purification: Affinity purified

Immunogen: Synthetic peptide surrounding amino acid 10 of human FKBP1A/FKBP12.

Application Details

Application Notes: Western Blot: 0.5-4 μg/mL. Immunoprecipitation: 2-10 μg/mL. Immunohistochemistry: 2-10 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: PBS, pH 7.2, containing 30 % glycerol, 0.5 % BSA, 0.01 % thimerosal.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C/-80 °C

Storage Comment: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.

Target Details for FKBP1A

Target: FKBP1A (FK506 Binding Protein 1A, 12kDa (FKBP1A))

Alternative Name: FKBP1A / FKBP12

Background: FKBP12 is a member of the family of soluble receptors capable of binding to one of two major immunosuppressant agents. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.Synonyms: FK506-binding protein 1A, Immunophilin FKBP12, PPIase FKBP1A, Peptidyl-prolyl cis-trans isomerase FKBP1A, Rotamase

Gene ID: 2280

NCBI Accession: NP_000792

UniProt: P62942

Pathways: Negative Regulation of Transporter Activity, Methionine Biosynthetic Process