FANCE antibody (AA 1-13)

Catalog No. ABIN129609

Supplier Product No.: 600-401-673

Product Details anti-FANCE Antibody

Target: FANCE (Fanconi Anemia, Complementation Group E (FANCE))

Binding Specificity: AA 1-13

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FANCE antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Supplier Product No.: 600-401-673

Supplier: Rockland

Purpose: FANCE Antibody

Characteristics: Synonyms: rabbit anti-FANCE antibody, FANC-E, FANC E, FACE antibody, FAE antibody, Fanconi anemia group E protein, Fanconi anemia complementation group E antibody

Purification: This is an affinity purified antibody produced by immunoaffinity chromatography using the immunizing peptide after immobilization to a solid phase.

Sterility: Sterile filtered

Immunogen:

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids 1-13 of Human FANCE. This Fanconi anemia protein promotes the nuclear accumulation of FANCC.  FANCE protein is part of the FA nuclear complex, binding FANCC & FANCD2. It is required for the nuclear accumulation of FANCC and provides a bridge between the FA complex and FANCD2. FANCC mutants do not bind FANCE or prevent chromosome breakage.  LocusLink ID 2178, SwissProt accession number Q9HB96

Immunogen Type: Conjugated Peptide

Isotype: IgG

Application Details

Application Notes:

Application Note: This affinity purified antibody has been tested for use in ELISA against the immunizing peptide.  Reactivity in other immunoassays is unknown.

Western Blot Dilution: 1:500- 1:2,000

ELISA Dilution: 1:10,000 - 1:50,000

Other: User Optimized

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Expiry Date: 12 months

Target Details for FANCE

Target: FANCE (Fanconi Anemia, Complementation Group E (FANCE))

Alternative Name: FANCE (FANCE Products)

Background: Background: Fanconi anemia group E protein (FANCE) is part of the Fanconi anemia (FA) complex functions in DNA cross-links repair. It is required for the nuclear accumulation of FANCC and provides a critical bridge between the FA complex and FANCD2.

Gene ID: 2178

NCBI Accession: NP_068741

UniProt: Q9HB96

Pathways: DNA Damage Repair