CD38 antibody

Catalog No. ABIN135205

This Rat Monoclonal antibody specifically detects CD38 in FACS, IP, ELISA, IHC (fro), Act, St, BR, DD, AD, Sep and CoSt. It exhibits reactivity toward Mouse.

Quick Overview for CD38 antibody (ABIN135205)

Target: CD38

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD38 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Activation (Act), Stimulation (St), Blocking Reagent (BR), Drug Delivery (DD), Apoptosis Detection (AD), Separation (Sep), Co-Stimulation (CoSt)

Clone: NIMR-5

Product Details anti-CD38 Antibody

Purpose: Rat Anti-Mouse CD38-LE/AF

Specificity: Mouse CD38, Mr 42 kDa

Characteristics: Low Endotoxin/Azide Free Anti-Mouse CD38 antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, ELISA, separation, activation, costimulation, stimulation, apoptosis, drug delivery, and blocking assays.

Endotoxin Level: Low Endotoxin

Immunogen: BCL1 plasma membrane glycoproteins

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Preservative: Azide free

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: 2-8°C

Target Details for CD38

Target: CD38

Background: Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCR+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.

Gene ID: 12494

UniProt: P56528