CD38 antibody

Catalog No. ABIN135210

The Rat Monoclonal anti-CD38 antibody (Clone 9E1) (ABIN135210) specifically detects CD38 in FACS, IP, IHC (fro) and St. The antibody is reactive with Mouse samples.

Quick Overview for CD38 antibody (ABIN135210)

Target: CD38

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD38 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Stimulation (St)

Clone: 9E1

Product Details anti-CD38 Antibody

Purpose: Rat Anti-Mouse CD38-LE/AF

Specificity: Mouse CD38, Mr 42 kDa

Characteristics: Low Endotoxin/Azide Free Anti-Mouse CD38 antibody for use in flow cytometry, immunohistochemistry, immunoprecipitation, and stimulation assays.

Endotoxin Level: Low Endotoxin

Immunogen: Mouse bone marrow pre-B cells

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Phosphate buffered saline, pH 7.4

Preservative: Azide free

Handling Advice: Each reagent is stable for the period shown on the bottle label if stored as directed.

Storage: 4 °C

Storage Comment: 2-8°C

Target Details for CD38

Target: CD38

Background: Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells, and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCR+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B- and T-cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.

Gene ID: 12494

UniProt: P56528