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GRP78 antibody

HSPA5 Reactivity: Mouse WB Host: Rat Monoclonal 76-E6 unconjugated
Catalog No. ABIN135301
  • Target See all GRP78 (HSPA5) Antibodies
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Reactivity
    • 195
    • 123
    • 105
    • 36
    • 35
    • 34
    • 32
    • 30
    • 30
    • 20
    • 14
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Mouse
    Host
    • 136
    • 96
    • 7
    • 3
    • 1
    • 1
    Rat
    Clonality
    • 140
    • 105
    Monoclonal
    Conjugate
    • 98
    • 19
    • 16
    • 12
    • 12
    • 12
    • 9
    • 8
    • 8
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This GRP78 antibody is un-conjugated
    Application
    • 212
    • 99
    • 87
    • 79
    • 77
    • 34
    • 28
    • 27
    • 26
    • 21
    • 13
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    Specificity
    Mouse BiP, Mr 78 kDa
    Characteristics
    Rat Anti-Mouse BiP-UNLB
    Purification
    Purified
    Immunogen
    Mouse BiP: chain complexes
    Clone
    76-E6
    Isotype
    IgG2a
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    Discover our top product HSPA5 Primary Antibody
  • Application Notes
    • Applications: WB - Quality tested , IP - Reported in literature , ELISA - Reported in literature
    • Working Dilutions: Immunoblotting Purified (UNLB) antibody 5 g/mL BIOT conjugate 5 g/mL
    Sample Volume
    1 mL
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline,  pH 8.2. No preservatives or amine-containing buffer salts added
    Preservative
    Without preservative
    Handling Advice
    Each reagent is stable for the period shown on the bottle label if stored as directed.
    Storage
    4 °C
    Storage Comment
    Store at 2-8°C
  • Target
    GRP78 (HSPA5) (Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) (HSPA5))
    Alternative Name
    BiP (HSPA5 Products)
    Background
    The immunoglobulin heavy chain binding protein BiP (Binding Protein) is a member of the hsp70 family of heat shock proteins, and is identical to the glucose regulated protein grp78.2 While BiP was originally described for its function in B cells, it is now known to be distributed in a variety of tissues, if not ubiquitous. The highly conserved hsp 70 proteins have an essential physiological role in stress responses and as molecular chaperones, which are responsible for a variety of functions such as protein transport, prevention of protein toxicity and direction of protein folding.1-5 With regard to its immunological role, BiP is a component of the endoplasmic reticulum and binds free intracellular heavy chains in nonsecreting pre-B cell lines (+,L-) or incompletely assembled Ig precursors in H+L+ secreting hybridomas and myelomas. In the absence of light chain synthesis, heavy chains remain associated with BiP and are not secreted. BiP is an ATP binding protein and the dissociation of the BiP-heavy chain complex is probably driven by the ATPase activity attributed to BiP.7
    Pathways
    Thyroid Hormone Synthesis, ER-Nucleus Signaling
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