IL-6 Receptor antibody

Catalog No. ABIN1383674

Product Details anti-IL-6 Receptor Antibody

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-6 Receptor antibody is un-conjugated

Application: Immunohistochemistry (IHC), Flow Cytometry (FACS)

Specificity: Recognises the Interleukin-6 Ra subunit, IL-6 Ra, IL-6 R, a 80 kDa protein

Purification: Ion exchange chromatography

Immunogen: gp80 transfected CHO cell line,Myeloma X63/AG.8653 x Balb/c spleen cells

Clone: B-R6

Isotype: IgG1 kappa

Application Details

Application Notes: Use 10 μL to label 10^6 cells or 100 μL of whole blood

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline with 1 % BSA and 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-IL-6 Receptor antibody (ABIN1383674)

Hess, Smola, Sandaradura De Silva, Hadaschik, Kube, Baldus, Flucke, Pfister: "Loss of IL-6 receptor expression in cervical carcinoma cells inhibits autocrine IL-6 stimulation: abrogation of constitutive monocyte chemoattractant protein-1 production." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 4, pp. 1939-48, (2000) (PubMed).

Target Details for IL-6 Receptor

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Alternative Name: CD126 (IL6R Products)

Background: IL-6R / gp80

Molecular Weight: 80 kDa

Pathways: JAK-STAT Signaling, Autophagy, Growth Factor Binding, Cancer Immune Checkpoints