IL-4 antibody

Catalog No. ABIN1383943

This Mouse Monoclonal antibody specifically detects IL-4 in IHC. It exhibits reactivity toward Human and has been mentioned in 7+ publications.

Quick Overview for IL-4 antibody (ABIN1383943)

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-4 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: B-S4

Product Details anti-IL-4 Antibody

Specificity: Recognises both natural and recombinant human IL-4

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: Recombinant human IL-4,Myeloma X63/AG.8653 x Balb/c spleen cells

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-IL-4 antibody (ABIN1383943)

Koido, Hara, Homma, Mitsunaga, Takahara, Nagasaki, Kawahara, Watanabe, Toyama, Yanagisawa, Kobayashi, Yanaga, Fujise, Gong, Tajiri: "Synergistic induction of antigen-specific CTL by fusions of TLR-stimulated dendritic cells and heat-stressed tumor cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 179, Issue 7, pp. 4874-83, (2007) (PubMed).

Todaro, Zerilli, Ricci-Vitiani, Bini, Perez Alea, Maria Florena, Miceli, Condorelli, Bonventre, Di Gesù, De Maria, Stassi: "Autocrine production of interleukin-4 and interleukin-10 is required for survival and growth of thyroid cancer cells." in: Cancer research, Vol. 66, Issue 3, pp. 1491-9, (2006) (PubMed).

Venet, Pachot, Debard, Bohe, Bienvenu, Lepape, Powell, Monneret: "Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 9, pp. 6540-7, (2006) (PubMed).

Koido, Hara, Homma, Torii, Mitsunaga, Yanagisawa, Toyama, Kawahara, Watanabe, Yoshida, Kobayashi, Yanaga, Fujise, Tajiri: "Streptococcal preparation OK-432 promotes fusion efficiency and enhances induction of antigen-specific CTL by fusions of dendritic cells and colorectal cancer cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 1, pp. 613-22, (2006) (PubMed).

Koido, Hara, Homma, Torii, Toyama, Kawahara, Watanabe, Yanaga, Fujise, Tajiri, Gong, Toda: "Dendritic cells fused with allogeneic colorectal cancer cell line present multiple colorectal cancer-specific antigens and induce antitumor immunity against autologous tumor cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 21, pp. 7891-900, (2005) (PubMed).

Conticello, Pedini, Zeuner, Patti, Zerilli, Stassi, Messina, Peschle, De Maria: "IL-4 protects tumor cells from anti-CD95 and chemotherapeutic agents via up-regulation of antiapoptotic proteins." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 9, pp. 5467-77, (2004) (PubMed).

Stassi, Todaro, Zerilli, Ricci-Vitiani, Di Liberto, Patti, Florena, Di Gaudio, Di Gesù, De Maria: "Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10." in: Cancer research, Vol. 63, Issue 20, pp. 6784-90, (2003) (PubMed).

Target Details for IL-4

Target: IL-4 (IL4) (Interleukin 4 (IL4))

Alternative Name: IL-4

Pathways: JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation