ARNTL2 antibody (AA 381-480)

Catalog No. ABIN1385567

The Rabbit Polyclonal anti-ARNTL2 antibody has been validated for WB, ELISA, IF (cc), IF (p), IHC (p), ICC and IHC (fro). It is suitable to detect ARNTL2 in samples from Human.

Quick Overview for ARNTL2 antibody (AA 381-480) (ABIN1385567)

Target: ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 (ARNTL2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARNTL2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ARNTL2 Antibody

Binding Specificity: AA 381-480

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ARNTL2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ARNTL2

Target: ARNTL2 (Aryl Hydrocarbon Receptor Nuclear Translocator-Like 2 (ARNTL2))

Alternative Name: ARNTL2/BMAL2

Background:

Synonyms: ARNT L2, ARNTL 2, ARNTL2, ARNTL2 protein, Aryl hydrocarbon receptor nuclear translocator like 2, Aryl hydrocarbon receptor nuclear translocator like protein 2, Aryl hydrocarbon receptor nuclear translocator-like 2, Basic helix loop helix PAS protein MOP9, Basic-helix-loop-helix-PAS protein MOP9, bHLHe6, BMA L2, BMAL 2, BMAL2, Brain and muscle ARNT like 2, Brain and muscle ARNT-like 2, CL, CYCLE like factor, CYCLE-like factor, Member of PAS protein 9, MGC124257, MGC149671, MGC149672, MGC158186, MOP 9, MOP9, PASD 9, PASD9, Transcription factor BMAL 2, Transcription factor BMAL2, wu:fj90c09, BMAL2_HUMAN.

Background: BMAL2 is a 636 amino acid protein that localizes to the nucleus and contains one bHLH (basic helix-loop-helix) domain, one PAC (PAS-associated C-terminal) domain and two PAS (PER-ARNT-SIM) domains. Expressed at high levels in placenta and brain and at lower levels in liver, thymus, heart, lung and kidney, BMAL2 functions as a component of the circadian core oscillator, which includes a variety of proteins that work in tandem to activate the transcription of target genes. More specifically, BMAL2, when functioning as a component of the core oscillator, binds to the E-box element (3'-CACGTG-5') of target DNA, thus inducing transcription. Multiple isoforms of BMAL2 exist due to alternative splicing events.

Gene ID: 56938

Pathways: Photoperiodism