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NOS1AP antibody (AA 128-170)

NOS1AP Reactivity: Human WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1385736
  • Target See all NOS1AP Antibodies
    NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))
    Binding Specificity
    • 14
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 128-170
    Reactivity
    • 44
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 41
    • 3
    • 1
    Rabbit
    Clonality
    • 44
    • 1
    Polyclonal
    Conjugate
    • 17
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This NOS1AP antibody is un-conjugated
    Application
    • 37
    • 21
    • 13
    • 12
    • 12
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CAPON
    Isotype
    IgG
    Top Product
    Discover our top product NOS1AP Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    NOS1AP (Nitric Oxide Synthase 1 (Neuronal) Adaptor Protein (NOS1AP))
    Alternative Name
    CAPON (NOS1AP Products)
    Synonyms
    MGC78853 antibody, Capon antibody, MGC145362 antibody, 6330408P19Rik antibody, CAPON antibody, nitric oxide synthase 1 adaptor protein antibody, nitric oxide synthase 1 adaptor protein L homeolog antibody, nitric oxide synthase 1 (neuronal) adaptor protein a antibody, carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein antibody, chromosome 18 C1orf226 homolog antibody, nitric oxide synthase 1 (neuronal) adaptor protein antibody, NOS1AP antibody, nos1ap.L antibody, nos1apa antibody, LOC609484 antibody, nos1ap antibody, LOC100058633 antibody, C18H1orf226 antibody, Nos1ap antibody
    Background

    Synonyms: NOS1AP, C terminal PDZ domain ligand of neuronal nitric oxide synthase CAPON, C terminal PDZ domain ligand of neuronal nitric oxide synthase, C terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ ligand of neuronal nitric oxide synthase protein, CAPON, CAPON_HUMAN, Carboxyl terminal PDZ ligand of neuronal nitric oxide synthase protein, Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, Ligand of neuronal nitric oxide synthase with carboxyl terminal PDZ domain, MGC138500, Nitric oxide synthase 1 neuronal adaptor protein, Nitric oxide synthase 1 adaptor protein.

    Background: CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.

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