ITM2C antibody (AA 3-88)

Catalog No. ABIN1386181

This Rabbit Polyclonal antibody specifically detects ITM2C in WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) and ICC. It exhibits reactivity toward Human.

Quick Overview for ITM2C antibody (AA 3-88) (ABIN1386181)

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITM2C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Product Details anti-ITM2C Antibody

Binding Specificity: AA 3-88

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ITM2C

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ITM2C

Target: ITM2C (Integral Membrane Protein 2C (ITM2C))

Alternative Name: ITM2C

Background:

Synonyms: BRI3, BRICD2C, BRICHOS domain containing 2C, Cerebral protein 14, CT-BRI3, E25, E25C , Integral membrane protein 2C, Integral membrane protein 3, Itm2c, ITM2C_HUMAN, ITM3 antibodyNPD018, Transmembrane protein BRI3.

Background: Negative regulator of beta amyloid peptide production. May inhibit the processing of APP by blocking its access to alpha-and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation.

Gene ID: 81618

UniProt: Q9NQX7