GRIK5 antibody (AA 201-300)

Catalog No. ABIN1386332

The Rabbit Polyclonal anti-GRIK5 antibody has been validated for WB, ELISA, IF (cc), IF (p), IHC (p), ICC and IHC (fro). It is suitable to detect GRIK5 in samples from Human.

Quick Overview for GRIK5 antibody (AA 201-300) (ABIN1386332)

Target: GRIK5 (Glutamate Receptor, Ionotropic, Kainate 5 (GRIK5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRIK5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-GRIK5 Antibody

Binding Specificity: AA 201-300

Predicted Reactivity: Human,Mouse,Rat,Dog,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GRIK5/KA2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for GRIK5

Target: GRIK5 (Glutamate Receptor, Ionotropic, Kainate 5 (GRIK5))

Alternative Name: GRIK5/KA2

Background:

Synonyms: EAA 2, EAA2, Excitatory amino acid receptor 2, GluRgamma2, Glutamate receptor, Glutamate receptor KA 2, Glutamate receptor KA-2, Glutamate receptor KA2, Glutamate receptor, ionotropic kainate 5 [Precursor], Glutamate receptor, ionotropic, kainate 5 gamma 2, Glutamate receptor, ionotropic, kainate 5, GRIK 2, GRIK 5, GRIK2, Grik5, GRIK5_HUMAN, iGlu5, ionotropic kainate 5, KA2, MGC118086.

Background: Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of the structurally related subunits GluR-1 to -7, KA1 and KA2. KA1 (also designated EEA1) and KA2 (also designated EEA2) form heteromeric receptors with GluR subunits when coexpressed, forming ion channels with various properties. The kainate/AMPA receptors are primarily responsible for the fast excitatory neuro-transmission by glutamate.

Pathways: Carbohydrate Homeostasis, Synaptic Membrane, Maintenance of Protein Location, Synaptic Vesicle Exocytosis