Lap1/Densin180 (AA 601-700) antibody

Catalog No. ABIN1386526

This Rabbit Polyclonal antibody specifically detects Lap1/Densin180 in ELISA, ICC, IF (cc), IF (p), IHC (fro) and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Lap1/Densin180 (AA 601-700) antibody (ABIN1386526)

Target: Lap1/Densin180

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Application: ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 601-700

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Densin180

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: Lap1/Densin180

Background:

Synonyms: Densin 180, Densin, Densin-180, densin180, DKFZp686I1147, KIAA1365, Lamin associated polypeptide 1, LAP 1, Leucine rich repeat containing 7, Leucine rich repeat containing protein 7, Leucine-rich repeat-containing protein 7,Lrrc 7, Lrrc7, LRRC7_HUMAN, MGC144918, OTTHUMP00000065336, OTTHUMP00000065337,OTTHUMP00000065338, Protein Lap 1, Protein lap1.

Background: Densin-180 is a synaptic transmembrane protein that is tightly associated with the postsynaptic density in CNS neurons and is postulated to function as a synaptic adhesion molecule. Densin-180 is a brain-specific momber of the O-sialoglycoprotein family which is highly concentrated at synapses along dendrites. The sequence of densin-180 contains 17 leucine-rich repeats, a sialomucin domain, an apparent transmembrane domain, and a PDZ (PSD-95, DIg, Z0-1) domain. The PDZ domain contributes to its binding to a-actinin. The intracellular portion of densin-180, CaMKIIa, interacts with a-actinin at distinct binding sites and, together, they form a ternary complex stabilized by multiple interactions.

Gene ID: 57554

UniProt: Q96NW7