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SIM2 antibody (AA 321-430)

SIM2 Reactivity: Human ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386626
  • Target See all SIM2 Antibodies
    SIM2 (Single-Minded Homolog 2 (SIM2))
    Binding Specificity
    • 14
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 321-430
    Reactivity
    • 29
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 26
    • 3
    • 1
    Rabbit
    Clonality
    • 28
    • 2
    Polyclonal
    Conjugate
    • 12
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SIM2 antibody is un-conjugated
    Application
    • 12
    • 12
    • 12
    • 11
    • 3
    • 3
    • 2
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
    Predicted Reactivity
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SIM2
    Isotype
    IgG
    Top Product
    Discover our top product SIM2 Primary Antibody
  • Application Notes
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    SIM2 (Single-Minded Homolog 2 (SIM2))
    Alternative Name
    SIM2 (SIM2 Products)
    Synonyms
    Xsim2 antibody, sim2-A antibody, xSim antibody, HMC13F06 antibody, HMC29C01 antibody, SIM antibody, bHLHe15 antibody, single-minded family bHLH transcription factor 2 S homeolog antibody, single-minded family bHLH transcription factor 2 antibody, single-minded homolog 2 (Drosophila) antibody, sim2.S antibody, sim2 antibody, SIM2 antibody, Sim2 antibody
    Background

    Synonyms: bHLHe15, Class E basic helix loop helix protein 15, Class E basic helix-loop-helix protein 15, MGC119447, SIM 2, SIM, Sim2, SIM2_HUMAN, Single minded homolog 2 Drosophila, Single minded homolog 2, Single-minded homolog 2, Transcription factor SIM2.

    Background: The Per-Arnt-Sim (PAS) domain was identified as a 270 amino acid motif that mediates associations between various PAS family transcription factors. Several PAS domain family members have been identified including AhR, Arnt 1, and single-minded proteins (SIM1 and SIM2). The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator protein 1 (Arnt 1) is required for ligand- dependent nuclear translocation of the Ah receptor and is also necessary for Ah receptor binding to the XRE element. Both SIM1 and SIM2 inhibit AhR/Arnt dimerization, thus inhibiting transcriptional activation. The SIM genes are thought to be involved in the directing and regionalization of tissues during development and the SIM2 gene, which is located on chromosome 21, is a candidate for the gene responsible for Down syndrome.

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