PATJ antibody (AA 1001-1200)

Catalog No. ABIN1386706

This Rabbit Polyclonal antibody specifically detects PATJ in ELISA, IF (cc), IF (p), IHC (p), IHC (fro) and ICC. It exhibits reactivity toward Human.

Quick Overview for PATJ antibody (AA 1001-1200) (ABIN1386706)

Target: PATJ (INADL) (InaD-Like (INADL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PATJ antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Product Details anti-PATJ Antibody

Binding Specificity: AA 1001-1200

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PATJ

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PATJ

Target: PATJ (INADL) (InaD-Like (INADL))

Alternative Name: PATJ

Background:

Synonyms: Channel interacting PDZ domain protein, Cipp, FLJ26982, hINADL, Inactivation no after potential D like protein, INAD like, InaD like Drosophila, INAD like protein, INADL, INADL protein, PALS 1 associated tight junction protein, PALS1 associated tight junction protein, PATJ, PDZ domain protein, PDZ domain protein Drosophila inaD like, Post synaptic density 95 / discs large / zonula occludens 1 domain protein, Protein associated to tight junctions, INADL_HUMAN .

Background: The membranes of myelinating Schwann cells are joined by tight, gap and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman and mesaxons. Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Pals-associated tight junction protein (PATJ), the human homolog of Drosophila Discs Lost, is differentially localized in myelinating Schwann cells. PATJ associates with Claudin-1, CRB1 (a transmembrane protein that plays a role in epithelial cell polarity and photoreceptor development), and Pals1 (a Lin-7 associated protein). The PATJ/Pals1/CRB1 complex can form a tripartite tight junction in epithelial cells crucial to their integrity.