PATJ antibody (N-Term)

Catalog No. ABIN2775641

Cited in 1 publication. The Rabbit Polyclonal anti-PATJ antibody (ABIN2775641) specifically detects PATJ in WB. The antibody is reactive with Human, Mouse, Cow, Rabbit, Dog, Guinea Pig, Horse and Rat samples.

Quick Overview for PATJ antibody (N-Term) (ABIN2775641)

Target: PATJ (INADL) (InaD-Like (INADL))

Reactivity: Human, Mouse, Cow, Rabbit, Dog, Guinea Pig, Horse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PATJ antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PATJ Antibody

Binding Specificity: N-Term

Purpose: PATJ Antibody - N-terminal region

Sequence: EVMVATLDTQ IADDAELQKY SKLLPIHTLR LGVEVDSFDG HHYISSIVSG

Predicted Reactivity: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%

Characteristics: This is a rabbit polyclonal antibody against INADL. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human INADL

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42938-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

References for anti-PATJ antibody (ABIN2775641)

Storrs, Silverstein: "PATJ, a tight junction-associated PDZ protein, is a novel degradation target of high-risk human papillomavirus E6 and the alternatively spliced isoform 18 E6." in: Journal of virology, Vol. 81, Issue 8, pp. 4080-90, (2007) (PubMed).

Target Details for PATJ

Target: PATJ (INADL) (InaD-Like (INADL))

Alternative Name: PATJ

Background:

Background Information: This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors.

Gene Name: PATJ, crumbs cell polarity complex component

Alternative Symbols: Cipp, INADL, hINADL, InaD-like

Protein Name: inaD-like protein

Molecular Weight: 196kDa

Gene ID: 10207

NCBI Accession: NP_795352

UniProt: Q8NI35