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FBXW8 antibody (AA 181-280)

FBXW8 Reactivity: Rat WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386823
  • Target See all FBXW8 Antibodies
    FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))
    Binding Specificity
    • 14
    • 7
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    AA 181-280
    Reactivity
    • 21
    • 15
    • 9
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Rat
    Host
    • 34
    • 1
    Rabbit
    Clonality
    • 35
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This FBXW8 antibody is un-conjugated
    Application
    • 34
    • 16
    • 13
    • 12
    • 12
    • 12
    • 4
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Cross-Reactivity
    Rat
    Predicted Reactivity
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FBXW8/FBXO29
    Isotype
    IgG
    Top Product
    Discover our top product FBXW8 Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    FBXW8 (F-Box and WD Repeat Domain Containing 8 (FBXW8))
    Alternative Name
    FBXW8 (FBXW8 Products)
    Synonyms
    FBW6 antibody, FBW8 antibody, FBX29 antibody, FBXO29 antibody, FBXW6 antibody, 4930438M06Rik antibody, Fbx29 antibody, F-box and WD repeat domain containing 8 antibody, ring finger protein, transmembrane 2 antibody, F-box and WD-40 domain protein 8 antibody, FBXW8 antibody, Fbxw8 antibody, RNFT2 antibody
    Background

    Synonyms: F box/WD repeat containing protein 8; F box and WD40 domain containing protein 8; F-box only protein 29; F box only protein 29; FBW6; FBW8; FBX29; FBXO29; FBXW6; FBXW8_HUMAN.

    Background: FBXO29, also designated F-box/WD repeat-containing protein 8 (FBXW8), is a 598 amino acid protein that contains one 40 amino acid F-box region, making it a member of the F-box family. FBXO29 also contains five WD repeats. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. F-box proteins are members of a large family that regulates cell cycle, immune response, signaling cascades and developmental programs by targeting proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-å and -catenin, for degradation by the proteasome after ubiquitination. Functioning as a component of the SCF complex, FBXO29 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation. FBXO29 exists as two isoforms as a result of alternative splicing events.

    Gene ID
    26259
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