ANKS1B antibody

Catalog No. ABIN1386929

The Rabbit Polyclonal anti-ANKS1B antibody is suitable to detect ANKS1B in samples from Human. It has been validated for IF, IHC (p) and IHC (fro).

Quick Overview for ANKS1B antibody (ABIN1386929)

Target: ANKS1B (Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANKS1B antibody is un-conjugated

Application: Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-ANKS1B Antibody

Purpose: ANKS1B Polyclonal Antibody

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ANKS1B/AIDA1

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for ANKS1B

Target: ANKS1B (Ankyrin Repeat and Sterile alpha Motif Domain Containing 1B (ANKS1B))

Alternative Name: ANKS1B

Background:

Synonyms: AIDA 1, AIDA-1, Amyloid-beta protein intracellular domain-associated protein 1, Anks1b, Ankyrin repeat and sterile alpha mot domain-containing protein 1B, ANS1B_HUMAN, E2A-PBX1-associated protein, EB-1.

Background: The _-Amyloid protein precursor (AbPP) is a widely expressed transmembrane protein that is processed into the b-Amyloid (Ab) peptide, which accumulates in insoluble plaques in the brain of Alzheimer?s disease patients and AbPP intracellular domain (AID). AID may function as a pro-apoptotic peptide, a regulator of calcium homeostasis and a molecule involved in transcriptional regulation. The AID associated protein 1 (AIDA-1) is highly expressed in the brain and is regulated by AbPP. It interacts with AbPP to play a role in brain development. AIDA-1 also interacts with coilin in Cajal bodies to regulate pre-mRNA splicing.

Gene ID: 56899

UniProt: Q7Z6G8