PIBF1 antibody

Catalog No. ABIN1387112

Product Details anti-PIBF1 Antibody

Target: PIBF1 (Progesterone Immunomodulatory Binding Factor 1 (PIBF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIBF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PIBF1/C13orf24

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PIBF1

Target: PIBF1 (Progesterone Immunomodulatory Binding Factor 1 (PIBF1))

Alternative Name: PIBF1 (PIBF1 Products)

Synonyms: D14Ertd581e antibody, 1700017E21Rik antibody, 4930513H15Rik antibody, 4933438D16Rik antibody, 4933439E17Rik antibody, RGD1305077 antibody, PIBF antibody, C13orf24 antibody, zgc:101063 antibody, MGC80410 antibody, CEP90 antibody, RP11-505F3.1 antibody, progesterone immunomodulatory binding factor 1 antibody, progesterone immunomodulatory binding factor 1 S homeolog antibody, Pibf1 antibody, PIBF1 antibody, pibf1 antibody, pibf1.S antibody

Background:

Synonyms: PIBF 1, PIBF, PIBF1, PIBF-1, Progesterone immunomodulatory binding factor 1, Progesterone induced blocking factor 1, Progesterone-Induced Blocking Factor 1, RP11 505F3.1, PIBF1_HUMAN, C13orf24.

Background: PIBF is synthesized during pregnancy in response to progesterone by progesterone receptor-positive T lymphocytes (mostly gamma-delta T cells). In the presence of PIBF, natural killer (NK) cells inhibit the release of perforin from storage granules and therefore fail to lyse target cells. In humans, the amount of cells that express PIBF is significantly higher in healthy pregnant women than in women at risk for premature pregnancy termination. Full-length PIBF is associated with the nucleus, whereas secretion of shorter forms is induced by activation of the cell. Research suggests that PIBF functions as a transcription factor in its full-length form, while smaller forms may act as cytokines. The PIBF gene encodes a deduced hydrophilic 757-amino acid alpha-helical protein with an N-terminal signal sequence, a leucine zipper motif, a basic zipper sequence, a PEST sequence, a nuclear localization signal, an endoplasmic reticulum membrane retention signal, and many presumeed N-glycosylation and phosphorylation sites.

Gene ID: 10464