PPP2R5C antibody (AA 390-435)

Catalog No. ABIN1387448

The Rabbit Polyclonal anti-PPP2R5C antibody is suitable to detect PPP2R5C in samples from Rat and Mouse. It has been validated for WB, ELISA, IF (cc), IF (p), ICC, IHC (fro) and IHC (p).

Quick Overview for PPP2R5C antibody (AA 390-435) (ABIN1387448)

Target: PPP2R5C (Protein Phosphatase 2, Regulatory Subunit B', gamma (PPP2R5C))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R5C antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PPP2R5C Antibody

Binding Specificity: AA 390-435

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PPP2R5C

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for PPP2R5C

Target: PPP2R5C (Protein Phosphatase 2, Regulatory Subunit B', gamma (PPP2R5C))

Alternative Name: PPP2R5C

Background:

Synonyms: 2A5G_HUMAN, B' alpha regulatory subunit, B56G, KIAA0044, MGC23064, PP2A B subunit B' gamma isoform, PP2A B subunit B56 gamma isoform, PP2A B subunit isoform B''-gamma, PP2A B subunit isoform B56-gamma, PP2A B subunit isoform PR61-gamma, PP2A B subunit isoform R5-gamma, PP2A B subunit PR61 gamma isoform, PP2A B subunit R5 gamma isoform, Ppp2r5c, PR61G, Protein phosphatase 2 regulatory subunit B B56 gamma isoform, Protein phosphatase 2 regulatory subunit B' gamma, Renal carcinoma antigen NY REN 29, Renal carcinoma antigen NY-REN-29, Serine/threonine protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, 2A5G_HUMAN.

Background: In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2A Alpha and PP2A Beta. The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-A-Alpha and -A-Beta, PP2A-B-Alpha and -B-Beta, PP2A-C-Alpha and -C-Beta, PP2A-B56-Alpha, -B56-Beta, -B56-gamma and -B56-Delta.

Pathways: PI3K-Akt Signaling