SLK antibody (AA 885-931)

Catalog No. ABIN1387496

Product Details anti-SLK Antibody

Target: SLK (STE20-Like Kinase (SLK))

Binding Specificity: AA 885-931

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLK antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Predicted Reactivity: Human,Mouse,Rat,Dog,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SLK

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SLK

Target: SLK (STE20-Like Kinase (SLK))

Alternative Name: STK2 (SLK Products)

Synonyms: BcDNA:LD05623 antibody, CG40293 antibody, Dmel\\CG40293 antibody, LD05623 antibody, LOSK antibody, STK2 antibody, bA16H23.1 antibody, se20-9 antibody, 9A2 antibody, AV021402 antibody, AW411554 antibody, Etk4 antibody, SMAK antibody, Stk2 antibody, mKIAA0204 antibody, mSLK antibody, STE20 like kinase antibody, Ste20-like kinase antibody, STE20-like kinase antibody, SLK antibody, Stlk antibody, Slk antibody

Background:

Synonyms: CTCL tumor antigen se20 9, LOSK, se20 9, Serine/threonine protein kinase 2, STK2, SLK, SNF1 sucrose nonfermenting like kinase, STE20 like serine/threonine-protein kinase, STE20 related kinase, STK2, SLK_HUMAN.

Background: SLK is a member of the serine/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase Ste20, a protein involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades. Members of this subfamily include KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, GC kinase, HGK and SLK. SLK is a ubiquitously expressed protein that localizes to the cytoplasm and contains an N-terminal protein kinase domain, a central coiled-coil domain and a C-terminal ATH domain. SLK is activated through cleavage by caspase-3. SLK indirectly associates with microtubules and plays an important role in cellular stress, cell motility, cell death and cytoskeletal dynamics.

UniProt: Q9H2G2